Oxygenated Preservation Solutions for Organ Preservation

Hyperbranched Polyglycerol as a Colloid in Cold Organ Preservation Solutions

Hydroxyethyl starch (HES) is a common colloid in organ preservation solutions, such as in University of Wisconsin (UW) solution, for preventing graft interstitial edema and cell swelling during cold preservation of donor organs. However, HES has undesirable characteristics, such as high viscosity, causing kidney injury and aggregation of erythrocytes. Hyperbranched polyglycerol (HPG) is a branc...

Glucose-containing organ preservation solutions and intracellular acidosis.

We read with interest the excellent review by Belzer and Southard (1) on the principles of organ preservation by cold storage following vascular flushing. The UW solution developed by the authors holds the promise that improved preservation will be achieved, especially for organs other than the kidney, both in duration of safe storage and in quality of function in the early postreimpiantation p...

Novel vs clinical organ preservation solutions: improved cardiac mitochondrial protection

BACKGROUND Heart transplantation remains the gold standard for end-stage heart failure, with current ex vivo organ storage times limited to 4 to 6 h before critical tissue damage occurs. Many preservation solutions exist in an attempt to limit both ischemic and reperfusion damage. In order to compare the effects of various storage solutions, mitochondrial function can be used to provide a sensi...

Organ preservation with the organ care system

Clinical heart transplantation is limited by the shortage of donor organs. The recent development of new donor organ maintenance systems may help to increase the utilization of available organs. This article reviews current experience with the Organ Care system for heart preservation.

Rheologic considerations in organ preservation.